Vanoi fever
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Vanoi fever, also known as Vanoi encephalitic fever (VEF)[note 1] and Vanoi hemorrhagic fever (VaHF)[note 2] is a viral hemorrhagic fever caused by the PC-60 virus that affects most mammalian sapient species. Vanoi fever was first identified in the Vanoi Medical Center in Voskakova, Valokchia in May 2018, and caused the following Vanoi fever pandemic.
| Vanoi fever | |
|---|---|
| Other names | Vanoi encephalitic fever[note 1], Vanoi hemorrhagic fever[note 2] |
 | |
| Transmission electron micrograph of PC-60 | |
| Specialty | Infectious diseases |
| Symptoms | Fever, cough, dizziness, meningitis, encephalitis, delirium, extreme aggression |
| Complications | Seizures, paralysis, hypovolemic shock |
| Usual onset | 2–21 days after exposure |
| Causes | PC-60 |
| Risk factors | Direct contact with blood of infected people |
| Diagnostic method | Blood test |
| Treatment | Supportive care |
Symptoms usually begin from two days to three weeks after exposure and initially takes the form of influenza-like illness, followed by progressive inflammation of the meninges and central nervous system causing paranoia and insomnia before resulting in extreme aggression resembling furious rabies. Vanoi fever has a fatality rate of about 93% once it is allowed to progress to a late stage.
Vanoi fever is spread primarily through direct contact with body fluids, especially blood. There have been a handful of documented cases of Vanoi fever spreading through air, though airborne transmission of Vanoi fever remains rare.
Signs and symtoms
Onset
Vanoi fever's incubation period, or the time it takes for symptoms to develop after initial exposure, is between 2 and 21 days, though about 60% of cases take between 4 and 10 days to develop.
The symptoms and severity of Vanoi fever vary between species but the disease is usually fatal if left untreated. Initial symptoms take the form of influenza-like illness characterized by fever, cough, fatigue, dizziness, and malaise.
Encephalitis
If not prevented, after about 7-10 days, the infection enters the central nervous system, causing progressive encephalitis and meningitis in 90% of untreated cases. This is accompanied by the onset of paranoia, insommnia, and eventually delirium by day 12-20.
After the onset of delirium, hosts become hyper-reactive to stimuli. This stage infamously causes extreme and irrational aggression in the host similar to that in rabies, which aids in the transmission of the virus through attacks from the host. Vanoi fever is typically fatal if it progresses to this "aggressive" stage.
As damage to the central nervous system worsens, hosts will typically start developing seizures and may become paralyzed due to damage to the spinal cord. Eventually the host falls into a coma, with death following shortly afterwards.
The incidence of encephalitis untreated cases varies by species and can be as high as 95% in vulnerable populations. Survivors are typically left with chronic health issues due to damage to the blood-brain barrier.
Bleeding
Regardless of whether encephalitis occurs, after 25-30 days of the infection, bleeding may occur, accompanied with decreased blood clotting. Petechiae, purpura, and hematomas may also develop. Blood loss may cause hypovolemic shock, which is the main cause of death among cases that do not develop encephalitis.
Vanoi fever was initially believed to not be a hemorrhagic fever due to the relatively late development of hemorrhagic symptoms compared to other viral hemorrhagic fevers, and since most early cases of Vanoi fever typically died due to encephalitic symptoms before hemorrhagic symptoms could develop.